N‐homocysteinylation of α‐synuclein promotes its aggregation and neurotoxicity

The aggregation of α‐synuclein plays a pivotal role in the pathogenesis of Parkinson's disease (PD). Epidemiological evidence indicates that high level of homocysteine (Hcy) is associated with an increased risk of PD. However, the molecular mechanisms remain elusive. Here, we report that homocy...

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Detalles Bibliográficos
Autores principales: Zhou, Lingyan, Guo, Tao, Meng, Lanxia, Zhang, Xingyu, Tian, Ye, Dai, Lijun, Niu, Xuan, Li, Yiming, Liu, Congcong, Chen, Guiqin, Liu, Chaoyang, Ke, Wei, Zhang, Zhaohui, Bao, Anyu, Zhang, Zhentao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10014048/
https://www.ncbi.nlm.nih.gov/pubmed/36437524
http://dx.doi.org/10.1111/acel.13745

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10014048/
https://www.ncbi.nlm.nih.gov/pubmed/36437524
http://dx.doi.org/10.1111/acel.13745

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