Cargando…

Quantitative systems pharmacology model of GITR‐mediated T cell dynamics in tumor microenvironment

T cell interaction in the tumor microenvironment is a key component of immuno‐oncology therapy. Glucocorticoid‐induced tumor necrosis factor receptor (TNFR)‐related protein (GITR) is expressed on immune cells including regulatory T cells (Tregs) and effector T cells (Teffs). Preclinical data suggest...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ji, Yan, Madrasi, Kumpal, Knee, Deborah A., Gruenbaum, Lore, Apgar, Joshua F., Burke, John M., Gomes, Bruce
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10014051/ https://www.ncbi.nlm.nih.gov/pubmed/36710369 http://dx.doi.org/10.1002/psp4.12925

Ejemplares similares

Systematic in silico analysis of clinically tested drugs for reducing amyloid‐beta plaque accumulation in Alzheimer's disease
por: Madrasi, Kumpal, et al.
Publicado: (2021)

Mathematical modeling of SARS-CoV-2 viral dynamics and treatment with monoclonal antibodies
por: Kareva, Irina, et al.
Publicado: (2022)

Investigation of the Dermal Absorption and Irritation Potential of Sertaconazole Nitrate Anhydrous Gel
por: Manian, Mahima, et al.
Publicado: (2016)

GITR and TIGIT immunotherapy provokes divergent multicellular responses in the tumor microenvironment of gastrointestinal cancers
por: Sathe, Anuja, et al.
Publicado: (2023)

GITR and TIGIT immunotherapy provokes divergent multi-cellular responses in the tumor microenvironment of gastrointestinal cancers
por: Sathe, Anuja, et al.
Publicado: (2023)

Quantitative Systems Pharmacology Model of a Masked, Tumor‐Activated Antibody
por: Stroh, Mark, et al.
Publicado: (2019)

Model‐informed drug development for immuno‐oncology agonistic anti‐GITR antibody GWN323: Dose selection based on MABEL and biologically active dose
por: Ji, Yan, et al.
Publicado: (2022)

NEDD4 Negatively Regulates GITR via Ubiquitination in Immune Microenvironment of Melanoma
por: Guo, Yu, et al.
Publicado: (2019)

An anti-PD-1–GITR-L bispecific agonist induces GITR clustering-mediated T cell activation for cancer immunotherapy
por: Chan, Sarah, et al.
Publicado: (2022)

Multiple mechanisms for TRAF3-mediated regulation of the T cell costimulatory receptor GITR
por: Li, Hanzeng, et al.
Publicado: (2021)

Impairment of Treg suppression by GITR ligation is effective selectively in the context of a pro-inflammatory tumor microenvironment
por: Zappasodi, Roberta, et al.
Publicado: (2014)

CD8(+) T Cells: GITR Matters
por: Ronchetti, Simona, et al.
Publicado: (2012)

Quantitative systems pharmacology modeling provides insight into inter‐mouse variability of Anti‐CTLA4 response
por: Qiao, Wenlian, et al.
Publicado: (2022)

Pharmacodynamic analysis of an agonistic antibody to the costimulatory receptor GITR
por: Moody, Gordon, et al.
Publicado: (2015)

Quantitative systems pharmacology model for Alzheimer’s disease to predict the effect of aducanumab on brain amyloid
por: Lin, Lin, et al.
Publicado: (2022)

The Role of GITR/GITRL Interaction in Autoimmune Diseases
por: Tian, Jie, et al.
Publicado: (2020)

Targeting GITR in cancer immunotherapy – there is no perfect knowledge
por: Davar, Diwakar, et al.
Publicado: (2023)

GITR ligation enhances functionality of tumor‐infiltrating T cells in hepatocellular carcinoma
por: van Beek, Adriaan A., et al.
Publicado: (2019)

The role of GITR single‐positive cells in immune homeostasis
por: Nocentini, Giuseppe, et al.
Publicado: (2017)

New emerging targets in cancer immunotherapy: the role of GITR
por: Buzzatti, Giulia, et al.
Publicado: (2020)

Expression of GITR Enhances Multiple Myeloma Cell Sensitivity to Bortezomib
por: Zhao, Yinghao, et al.
Publicado: (2015)

GITR-GITRL System, A Novel Player in Shock and Inflammation
por: Krausz, Ludovic Tibor, et al.
Publicado: (2007)

Optimal target saturation of ligand-blocking anti-GITR antibody IBI37G5 dictates FcγR-independent GITR agonism and antitumor activity
por: Liu, Huisi, et al.
Publicado: (2022)

Novel Tumor Suppressor Function of Glucocorticoid-Induced TNF Receptor GITR in Multiple Myeloma
por: Liu, Yang, et al.
Publicado: (2013)

Enhanced CD8 T Cell Responses through GITR-Mediated Costimulation Resolve Chronic Viral Infection
por: Pascutti, Maria Fernanda, et al.
Publicado: (2015)

In vitro up-regulation of expression of GITR on human CD8+ cells
por: Thanavala, Yasmin
Publicado: (2009)

GITR Activation Positively Regulates Immune Responses against Toxoplasma gondii
por: Costa, Frederico R. C., et al.
Publicado: (2016)

Quantitative systems toxicology
por: Bloomingdale, Peter, et al.
Publicado: (2017)

GITR Ligation Improves Anti-PD1-Mediated Restoration of Human MMR-Proficient Colorectal Carcinoma Tumor-Derived T Cells
por: Rakké, Yannick S., et al.
Publicado: (2022)

The use of anti-GITR antibody treatment in a murine model of glioblastoma multiforme
por: Miska, Jason, et al.
Publicado: (2015)

GITR Promotes the Polarization of TFH-Like Cells in Helicobacter pylori-Positive Gastritis
por: Ming, Siqi, et al.
Publicado: (2021)

Targeting Treg cells with GITR activation alleviates resistance to immunotherapy in murine glioblastomas
por: Amoozgar, Zohreh, et al.
Publicado: (2021)

Agonist anti-GITR monoclonal antibody and stereotactic radiation induce immune-mediated survival advantage in murine intracranial glioma
por: Patel, Mira, et al.
Publicado: (2015)

Agonist anti-GITR monoclonal antibody and stereotactic radiation induce immune-mediated survival advantage in murine intracranial glioma
por: Patel, Mira A., et al.
Publicado: (2016)

Structures of mouse and human GITR–GITRL complexes reveal unique TNF superfamily interactions
por: Wang, Feng, et al.
Publicado: (2021)

Cyclophosphamide enhances the antitumor potency of GITR engagement by increasing oligoclonal cytotoxic T cell fitness
por: Hirschhorn, Daniel, et al.
Publicado: (2021)

Blocking the GITR-GITRL pathway to overcome resistance to therapy in sarcomatoid malignant pleural mesothelioma
por: Chan, Meilin, et al.
Publicado: (2021)

Erratum to: Agonist anti-GITR monoclonal antibody and stereotactic radiation induce immune-mediated survival advantage in murine intracranial glioma
por: Patel, Mira A., et al.
Publicado: (2016)

Correlation of Increased Blood Levels of GITR and GITRL with Disease Severity in Patients with Primary Sjögren's Syndrome
por: Gan, Xiaoxia, et al.
Publicado: (2013)

Influenza-Activated ILC1s Contribute to Antiviral Immunity Partially Influenced by Differential GITR Expression
por: Vashist, Neha, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_l7l0k1jiddppaffgograa6qv9g