Protein phosphatase 2A activators reverse age‐related behavioral changes by targeting neural cell senescence

The contribution of cellular senescence to the behavioral changes observed in the elderly remains elusive. Here, we observed that aging is associated with a decline in protein phosphatase 2A (PP2A) activity in the brains of zebrafish and mice. Moreover, drugs activating PP2A reversed age‐related beh...

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Detalles Bibliográficos
Autores principales: Xing, Jun, Chen, Kehua, Gao, Shuaiyun, Pousse, Mélanie, Ying, Yilin, Wang, Bo, Chen, Lianxiang, Wang, Cuicui, Wang, Lei, Hu, Weiguo, Lu, Yiming, Gilson, Eric, Ye, Jing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10014060/
https://www.ncbi.nlm.nih.gov/pubmed/36644807
http://dx.doi.org/10.1111/acel.13780

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10014060/
https://www.ncbi.nlm.nih.gov/pubmed/36644807
http://dx.doi.org/10.1111/acel.13780

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