Reversine ameliorates hallmarks of cellular senescence in human skeletal myoblasts via reactivation of autophagy

Cellular senescence leads to the depletion of myogenic progenitors and decreased regenerative capacity. We show that the small molecule 2,6‐disubstituted purine, reversine, can improve some well‐known hallmarks of cellular aging in senescent myoblast cells. Reversine reactivated autophagy and insuli...

Descripción completa

Detalles Bibliográficos
Autores principales: Rajabian, Nika, Choudhury, Debanik, Ikhapoh, Izuagie, Saha, Shilpashree, Kalyankar, Aishwarya S., Mehrotra, Pihu, Shahini, Aref, Breed, Kendall, Andreadis, Stelios T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10014065/
https://www.ncbi.nlm.nih.gov/pubmed/36625257
http://dx.doi.org/10.1111/acel.13764

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10014065/
https://www.ncbi.nlm.nih.gov/pubmed/36625257
http://dx.doi.org/10.1111/acel.13764

Ejemplares similares