The ubiquitin ligase TRIM21 regulates mutant p53 accumulation and gain of function in cancer

The tumor suppressor TP53 is the most frequently mutated gene in human cancers. Mutant p53 (mutp53) proteins often accumulate to very high levels in human cancers to promote cancer progression through the gain-of-function (GOF) mechanism. Currently, the mechanism underlying mutp53 accumulation and G...

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Detalles Bibliográficos
Autores principales: Liu, Juan, Zhang, Cen, Xu, Dandan, Zhang, Tianliang, Chang, Chun-Yuan, Wang, Jianming, Liu, Jie, Zhang, Lanjing, Haffty, Bruce G., Zong, Wei-Xing, Hu, Wenwei, Feng, Zhaohui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10014102/
https://www.ncbi.nlm.nih.gov/pubmed/36749630
http://dx.doi.org/10.1172/JCI164354

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10014102/
https://www.ncbi.nlm.nih.gov/pubmed/36749630
http://dx.doi.org/10.1172/JCI164354

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