A terpene nucleoside from M. tuberculosis induces lysosomal lipid storage in foamy macrophages

Induction of lipid-laden foamy macrophages is a cellular hallmark of tuberculosis (TB) disease, which involves the transformation of infected phagolysosomes from a site of killing into a nutrient-rich replicative niche. Here, we show that a terpenyl nucleoside shed from Mycobacterium tuberculosis, 1...

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Detalles Bibliográficos
Autores principales: Bedard, Melissa, van der Niet, Sanne, Bernard, Elliott M., Babunovic, Gregory, Cheng, Tan-Yun, Aylan, Beren, Grootemaat, Anita E., Raman, Sahadevan, Botella, Laure, Ishikawa, Eri, O’Sullivan, Mary P., O’Leary, Seónadh, Mayfield, Jacob A., Buter, Jeffrey, Minnaard, Adriaan J., Fortune, Sarah M., Murphy, Leon O., Ory, Daniel S., Keane, Joseph, Yamasaki, Sho, Gutierrez, Maximiliano G., van der Wel, Nicole, Moody, D. Branch
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10014106/
https://www.ncbi.nlm.nih.gov/pubmed/36757797
http://dx.doi.org/10.1172/JCI161944

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10014106/
https://www.ncbi.nlm.nih.gov/pubmed/36757797
http://dx.doi.org/10.1172/JCI161944

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