PP2Ac/STRN4 negatively regulates STING-type I IFN signaling in tumor-associated macrophages

Stimulator of IFN genes type I (STING-Type I) IFN signaling in myeloid cells plays a critical role in effective antitumor immune responses, but STING agonists as monotherapy have shown limited efficacy in clinical trials. The mechanisms that downregulate STING signaling are not fully understood. Her...

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Detalles Bibliográficos
Autores principales: Ho, Winson S., Mondal, Isha, Xu, Beisi, Das, Oishika, Sun, Raymond, Chiou, Pochin, Cai, Xiaomin, Tahmasebinia, Foozhan, McFadden, Elizabeth, Wu, Caren Yu-Ju, Wu, Zhihao, Matsui, William, Lim, Michael, Meng, Zhipeng, Lu, Rongze Olivia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10014107/
https://www.ncbi.nlm.nih.gov/pubmed/36757811
http://dx.doi.org/10.1172/JCI162139

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10014107/
https://www.ncbi.nlm.nih.gov/pubmed/36757811
http://dx.doi.org/10.1172/JCI162139

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