PP2Ac/STRN4 negatively regulates STING-type I IFN signaling in tumor-associated macrophages

Stimulator of IFN genes type I (STING-Type I) IFN signaling in myeloid cells plays a critical role in effective antitumor immune responses, but STING agonists as monotherapy have shown limited efficacy in clinical trials. The mechanisms that downregulate STING signaling are not fully understood. Her...

Descripción completa

Detalles Bibliográficos
Autores principales: Ho, Winson S., Mondal, Isha, Xu, Beisi, Das, Oishika, Sun, Raymond, Chiou, Pochin, Cai, Xiaomin, Tahmasebinia, Foozhan, McFadden, Elizabeth, Wu, Caren Yu-Ju, Wu, Zhihao, Matsui, William, Lim, Michael, Meng, Zhipeng, Lu, Rongze Olivia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10014107/
https://www.ncbi.nlm.nih.gov/pubmed/36757811
http://dx.doi.org/10.1172/JCI162139

Ejemplares similares

Ejemplares similares