Cargando…

Non-canonical function of DPP4 promotes cognitive impairment through ERp29-associated mitochondrial calcium overload in diabetes

DPP4 has been shown to induce diabetes-associated mitochondrial dysfunction and cognitive impairment through its non-canonical function. Here, we report that enhanced DPP4 expression in diabetes contributes to IP3R2-mediated mitochondria-associated ER membrane (MAM) formation, mitochondria calcium o...

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, Jiaxiu, Hui, Ya, Xu, Zhiqiang, Tan, Jie, Yin, Kai, Kuang, Liuyu, Tang, Yunyun, Wei, Junjie, Zhong, Qiongsui, Zheng, Tianpeng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10014273/ https://www.ncbi.nlm.nih.gov/pubmed/36936785 http://dx.doi.org/10.1016/j.isci.2023.106271

Ejemplares similares

Calcium Overload and Mitochondrial Metabolism
por: Walkon, Lauren L., et al.
Publicado: (2022)

The Probable, Possible, and Novel Functions of ERp29
por: Brecker, Margaret, et al.
Publicado: (2020)

ERp29 as a regulator of Insulin biosynthesis
por: Viviano, Jeffrey, et al.
Publicado: (2020)

DPP8/DPP9 inhibition elicits canonical Nlrp1b inflammasome hallmarks in murine macrophages
por: de Vasconcelos, Nathalia M, et al.
Publicado: (2019)

Modeling the Effects of Calcium Overload on Mitochondrial Ultrastructural Remodeling
por: Strubbe-Rivera, Jasiel O., et al.
Publicado: (2021)

Friend or foe: Endoplasmic reticulum protein 29 (ERp29) in epithelial cancer
por: Chen, Shaohua, et al.
Publicado: (2015)

Correction: ERp29 as a regulator of Insulin biosynthesis
por: Viviano, Jeffrey, et al.
Publicado: (2020)

The antidepressant fluoxetine induces necrosis by energy depletion and mitochondrial calcium overload
por: Charles, Emilie, et al.
Publicado: (2016)

Endoplasmic reticulum protein 29 (ERp29) as a novel prognostic marker and tumor suppressor in osteosarcoma
por: Chaiyawat, Parunya, et al.
Publicado: (2019)

ApoE4 (Δ272–299) induces mitochondrial‐associated membrane formation and mitochondrial impairment by enhancing GRP75-modulated mitochondrial calcium overload in neuron
por: Liang, Tao, et al.
Publicado: (2021)

Mitochondrial Calcium Overload Plays a Causal Role in Oxidative Stress in the Failing Heart
por: Dridi, Haikel, et al.
Publicado: (2023)

Identification of ERp29 as a biomarker for predicting nasopharyngeal carcinoma response to radiotherapy
por: WU, PING, et al.
Publicado: (2011)

ERp29 inhibits tumorigenicity by suppressing epithelial mesenchymal transition in gastric cancer
por: Wu, Jing, et al.
Publicado: (2017)

Impaired cellular bioenergetics caused by GBA1 depletion sensitizes neurons to calcium overload
por: Plotegher, Nicoletta, et al.
Publicado: (2019)

The Relationship Between Plasma DPP4 Activity to BDNF Ratio and Mild Cognitive Impairment in Elderly Population With Normal Glucose Tolerance
por: Xiao, Liuping, et al.
Publicado: (2019)

ER calcium release promotes mitochondrial dysfunction and hepatic cell lipotoxicity in response to palmitate overload
por: Egnatchik, Robert A., et al.
Publicado: (2014)

Iron Overload, Oxidative Stress and Calcium Mishandling in Cardiomyocytes: Role of the Mitochondrial Permeability Transition Pore
por: Gordan, Richard, et al.
Publicado: (2020)

Akkermansia muciniphila induces mitochondrial calcium overload and α -synuclein aggregation in an enteroendocrine cell line
por: Amorim Neto, Dionísio Pedro, et al.
Publicado: (2022)

Mild Traumatic Brain Injury Induces Mitochondrial Calcium Overload and Triggers the Upregulation of NCLX in the Hippocampus
por: Mira, Rodrigo G., et al.
Publicado: (2023)

RYR2-ryanodinopathies: from calcium overload to calcium deficiency
por: Steinberg, Christian, et al.
Publicado: (2023)

Endoplasmic reticulum protein 29 (ERp29), a protein related to sperm maturation is involved in sperm-oocyte fusion in mouse
por: Ying, Xiaoqian, et al.
Publicado: (2010)

ERp29 Attenuates Nicotine-Induced Endoplasmic Reticulum Stress and Inhibits Choroidal Neovascularization
por: Lu, Tu, et al.
Publicado: (2023)

Nobiletin attenuates neurotoxic mitochondrial calcium overload through K(+) influx and ΔΨ(m) across mitochondrial inner membrane
por: Lee, Ji Hyung, et al.
Publicado: (2018)

The mitochondrial permeability transition phenomenon elucidated by cryo-EM reveals the genuine impact of calcium overload on mitochondrial structure and function
por: Strubbe-Rivera, Jasiel O., et al.
Publicado: (2021)

Correction: Impaired cellular bioenergetics caused by GBA1 depletion sensitizes neurons to calcium overload
por: Plotegher, Nicoletta, et al.
Publicado: (2020)

Oxidative stress, mitochondrial dysfunction and calcium overload in human lamina cribrosa cells from glaucoma donors
por: McElnea, E.M., et al.
Publicado: (2011)

Inhibition of nuclear deacetylase Sirtuin-1 induces mitochondrial acetylation and calcium overload leading to cell death
por: Sun, Yue, et al.
Publicado: (2022)

Visible‐Light‐Activated Molecular Machines Kill Fungi by Necrosis Following Mitochondrial Dysfunction and Calcium Overload
por: Santos, Ana L., et al.
Publicado: (2023)

Small Interfering RNA Targeting Mitochondrial Calcium Uniporter Improves Cardiomyocyte Cell Viability in Hypoxia/Reoxygenation Injury by Reducing Calcium Overload
por: Oropeza-Almazán, Yuriana, et al.
Publicado: (2017)

The Regulatory Roles of Mitochondrial Calcium and the Mitochondrial Calcium Uniporter in Tumor Cells
por: Zhang, Linlin, et al.
Publicado: (2022)

miR-29a inhibits proliferation, invasion, and migration of papillary thyroid cancer by targeting DPP4
por: Wang, Yufei, et al.
Publicado: (2019)

Non-heme iron overload impairs monocyte to macrophage differentiation via mitochondrial oxidative stress
por: Cui, Yue, et al.
Publicado: (2022)

Social exclusion modulates fairness consideration in the ultimatum game: an ERP study
por: Qu, Chen, et al.
Publicado: (2013)

Canonical Wnt Signaling in the Pathology of Iron Overload-Induced Oxidative Stress and Age-Related Diseases
por: Armstrong, Austin, et al.
Publicado: (2022)

Immediate response of myocardium to pressure overload includes transient regulation of genes associated with mitochondrial bioenergetics and calcium availability
por: Deckmann, Ana Carolina, et al.
Publicado: (2010)

Neurokinin-1 receptor is an effective target for treating leukemia by inducing oxidative stress through mitochondrial calcium overload
por: Ge, Chentao, et al.
Publicado: (2019)

Changes in the Stoichiometry of Uniplex Decrease Mitochondrial Calcium Overload and Contribute to Tolerance of Cardiac Ischemia/Reperfusion Injury in Hypothyroidism
por: Chapoy-Villanueva, Héctor, et al.
Publicado: (2019)

Restriction of mitochondrial calcium overload by mcu inactivation renders a neuroprotective effect in zebrafish models of Parkinson's disease
por: Soman, Smijin K., et al.
Publicado: (2019)

Calcium chelator BAPTA-AM protects against iron overload-induced chondrocyte mitochondrial dysfunction and cartilage degeneration
por: Jing, Xingzhi, et al.
Publicado: (2021)

Calcium Overload or Underload? The Effects of Doxorubicin on the Calcium Dynamics in Guinea Pig Hearts
por: Wu, Jingjing, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_bsjdihb994m5ghcl0ggb68furo