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Highly selective transgene expression through the flip-excision switch system by using a unilateral spacer sequence
The flip-excision switch (FLEX) system with an adeno-associated viral (AAV) vector allows expression of transgenes in specific cell populations having Cre recombinase. A significant issue with this system is non-specific expression of transgenes in tissues after vector injection. We show here that C...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10014282/ https://www.ncbi.nlm.nih.gov/pubmed/36936079 http://dx.doi.org/10.1016/j.crmeth.2022.100393 |