Neuronal loss of NCLX-dependent mitochondrial calcium efflux mediates age-associated cognitive decline

Mitochondrial calcium overload contributes to neurodegenerative disease development and progression. We recently reported that loss of the mitochondrial sodium/calcium exchanger (NCLX), the primary mechanism of (m)Ca(2+) efflux, promotes (m)Ca(2+) overload, metabolic derangement, redox stress, and c...

Descripción completa

Detalles Bibliográficos
Autores principales: Jadiya, Pooja, Cohen, Henry M., Kolmetzky, Devin W., Kadam, Ashlesha A., Tomar, Dhanendra, Elrod, John W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10014305/
https://www.ncbi.nlm.nih.gov/pubmed/36936788
http://dx.doi.org/10.1016/j.isci.2023.106296

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10014305/
https://www.ncbi.nlm.nih.gov/pubmed/36936788
http://dx.doi.org/10.1016/j.isci.2023.106296

Ejemplares similares