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Neuronal loss of NCLX-dependent mitochondrial calcium efflux mediates age-associated cognitive decline

Mitochondrial calcium overload contributes to neurodegenerative disease development and progression. We recently reported that loss of the mitochondrial sodium/calcium exchanger (NCLX), the primary mechanism of (m)Ca(2+) efflux, promotes (m)Ca(2+) overload, metabolic derangement, redox stress, and c...

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Detalles Bibliográficos
Autores principales:	Jadiya, Pooja, Cohen, Henry M., Kolmetzky, Devin W., Kadam, Ashlesha A., Tomar, Dhanendra, Elrod, John W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10014305/ https://www.ncbi.nlm.nih.gov/pubmed/36936788 http://dx.doi.org/10.1016/j.isci.2023.106296

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