Pharmacokinetics, pharmacodynamics, safety and tolerability of cilofexor, a novel nonsteroidal Farnesoid X receptor agonist, in healthy volunteers

Cilofexor is a nonsteroidal farnesoid X receptor (FXR) agonist being evaluated for treatment of nonalcoholic steatohepatitis (NASH) and primary sclerosing cholangitis (PSC). This work characterized the pharmacokinetics, pharmacodynamic, safety, and tolerability of cilofexor in healthy participants....

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Detalles Bibliográficos
Autores principales: Younis, Islam R., Kirby, Brian J., Billin, Andrew N., Xiao, Deqing, Song, Qinghua, Watkins, Timothy R., Othman, Ahmed A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10014688/
https://www.ncbi.nlm.nih.gov/pubmed/36573450
http://dx.doi.org/10.1111/cts.13469

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10014688/
https://www.ncbi.nlm.nih.gov/pubmed/36573450
http://dx.doi.org/10.1111/cts.13469

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