In vivo human keyhole limpet hemocyanin challenge in early phase drug development: A systematic review

Experimental exposure of healthy volunteers to the T‐cell dependent neoantigen keyhole limpet hemocyanin (KLH) permits the evaluation of immunomodulatory investigational medicinal product (IMP) pharmacology prior to the recruitment of patient populations. Despite widespread use, no standardized appr...

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Detalles Bibliográficos
Autores principales: Drennan, Philip G., Karponis, Dimitrios, Richards, Duncan, Coles, Mark, Fullerton, James N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Reviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10014697/
https://www.ncbi.nlm.nih.gov/pubmed/36420645
http://dx.doi.org/10.1111/cts.13457

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10014697/
https://www.ncbi.nlm.nih.gov/pubmed/36420645
http://dx.doi.org/10.1111/cts.13457

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