Cargando…

The impact of genetic variability in urate transporters on oxypurinol pharmacokinetics

The genetic determinants of the allopurinol dose‐concentration relationship have not been extensively studied. We aimed to clarify what factors, including genetic variation in urate transporters, influence oxypurinol pharmacokinetics (PKs). A population PK model for oxypurinol was developed with NON...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hishe, Hailemichael Z., Stocker, Sophie L., Stamp, Lisa K., Dalbeth, Nicola, Merriman, Tony R., Phipps‐Green, Amanda, Wright, Daniel F. B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2022
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10014700/ https://www.ncbi.nlm.nih.gov/pubmed/36398357 http://dx.doi.org/10.1111/cts.13460

Ejemplares similares

Relationships Between Allopurinol Dose, Oxypurinol Concentration and Urate‐Lowering Response—In Search of a Minimum Effective Oxypurinol Concentration
por: Stamp, Lisa K., et al.
Publicado: (2019)

Association analysis of the SLC22A11 (organic anion transporter 4) and SLC22A12 (urate transporter 1) urate transporter locus with gout in New Zealand case-control sample sets reveals multiple ancestral-specific effects
por: Flynn, Tanya J, et al.
Publicado: (2013)

Body mass index modulates the relationship of sugar-sweetened beverage intake with serum urate concentrations and gout
por: Dalbeth, Nicola, et al.
Publicado: (2015)

Longitudinal development of incident gout from low-normal baseline serum urate concentrations: individual participant data analysis
por: Robinson, Philip C., et al.
Publicado: (2021)

Is repeat serum urate testing superior to a single test to predict incident gout over time?
por: Stewart, Sarah, et al.
Publicado: (2022)

The renal urate transporter SLC17A1 locus: confirmation of association with gout
por: Hollis-Moffatt, Jade E, et al.
Publicado: (2012)

Association of SLC2A9 genotype with phenotypic variability of serum urate in pre-menopausal women
por: Topless, Ruth K., et al.
Publicado: (2015)

Population-specific association between ABCG2 variants and tophaceous disease in people with gout
por: He, Wendy, et al.
Publicado: (2017)

The relationship between ferritin and urate levels and risk of gout
por: Fatima, Tahzeeb, et al.
Publicado: (2018)

Sugar-sweetened beverage consumption: a risk factor for prevalent gout with SLC2A9 genotype-specific effects on serum urate and risk of gout
por: Batt, Caitlin, et al.
Publicado: (2014)

Interactions between serum urate-associated genetic variants and sex on gout risk: analysis of the UK Biobank
por: Narang, Ravi K., et al.
Publicado: (2019)

Influence of the ABCG2 gout risk 141 K allele on urate metabolism during a fructose challenge
por: Dalbeth, Nicola, et al.
Publicado: (2014)

Population-specific factors associated with fractional excretion of uric acid
por: Narang, Ravi K., et al.
Publicado: (2019)

The ABCG2 Q141K hyperuricemia and gout associated variant illuminates the physiology of human urate excretion
por: Hoque, Kazi Mirajul, et al.
Publicado: (2020)

Effect of body mass index on serum urate and renal uric acid handling responses to an oral inosine load: experimental intervention study in healthy volunteers
por: Dalbeth, Nicola, et al.
Publicado: (2020)

Effects of elevated serum urate on cardiometabolic and kidney function markers in a randomised clinical trial of inosine supplementation
por: Dalbeth, Nicola, et al.
Publicado: (2022)

Pleiotropic effect of the ABCG2 gene in gout: involvement in serum urate levels and progression from hyperuricemia to gout
por: Wrigley, Rebekah, et al.
Publicado: (2020)

Gout, Rheumatoid Arthritis, and the Risk of Death Related to Coronavirus Disease 2019: An Analysis of the UK Biobank
por: Topless, Ruth K., et al.
Publicado: (2021)

Positive association of tomato consumption with serum urate: support for tomato consumption as an anecdotal trigger of gout flares
por: Flynn, Tanya J, et al.
Publicado: (2015)

Evaluation of the diet wide contribution to serum urate levels: meta-analysis of population based cohorts
por: Major, Tanya J, et al.
Publicado: (2018)

The genetics of gout: towards personalised medicine?
por: Dalbeth, Nicola, et al.
Publicado: (2017)

Urate-induced epigenetic modifications in myeloid cells
por: Badii, M., et al.
Publicado: (2021)

Interaction of the GCKR and A1CF loci with alcohol consumption to influence the risk of gout
por: Rasheed, Humaira, et al.
Publicado: (2017)

Gout Remission as a Goal of Urate-Lowering Therapy: A Critical Review
por: Tabi-Amponsah, Adwoa Dansoa, et al.
Publicado: (2023)

Influence of genetic variants on renal uric acid handling in response to frusemide: an acute intervention study
por: Dalbeth, Nicola, et al.
Publicado: (2017)

Oxypurinol pharmacokinetics and pharmacodynamics in healthy volunteers: Influence of BCRP Q141K polymorphism and patient characteristics
por: Vora, Bianca, et al.
Publicado: (2021)

A machine learning-assisted model for renal urate underexcretion with genetic and clinical variables among Chinese men with gout
por: Sun, Mingshu, et al.
Publicado: (2022)

How much allopurinol does it take to get to target urate? Comparison of actual dose with creatinine clearance-based dose
por: Stamp, Lisa K., et al.
Publicado: (2018)

Allopurinol and oxypurinol promote osteoblast differentiation and increase bone formation
por: Orriss, Isabel R., et al.
Publicado: (2016)

Allopurinol and oxypurinol differ in their strength and mechanisms of inhibition of xanthine oxidoreductase
por: Sekine, Mai, et al.
Publicado: (2023)

Urate crystal deposition and bone erosion in gout: ‘inside-out’ or ‘outside-in’? A dual-energy computed tomography study
por: Towiwat, Patapong, et al.
Publicado: (2016)

Sugar Sweetened Beverage Consumption among Adults with Gout or Type 2 Diabetes
por: Murphy, Rinki, et al.
Publicado: (2015)

The relationship of apolipoprotein B and very low density lipoprotein triglyceride with hyperuricemia and gout
por: Rasheed, Humaira, et al.
Publicado: (2014)

Association of the lipoprotein receptor-related protein 2 gene with gout and non-additive interaction with alcohol consumption
por: Rasheed, Humaira, et al.
Publicado: (2013)

Using serum urate as a validated surrogate end point for flares in patients with gout: protocol for a systematic review and meta-regression analysis
por: Morillon, Melanie B, et al.
Publicado: (2016)

Urate in fingernail represents the deposition of urate burden in gout patients
por: Chen, Haibing, et al.
Publicado: (2020)

Gout and the risk of COVID-19 diagnosis and death in the UK Biobank: a population-based study
por: Topless, Ruth K, et al.
Publicado: (2022)

The ITGAV rs3738919 variant and susceptibility to rheumatoid arthritis in four Caucasian sample sets
por: Hollis-Moffatt, Jade E, et al.
Publicado: (2009)

GWAS of clinically defined gout and subtypes identifies multiple susceptibility loci that include urate transporter genes
por: Nakayama, Akiyoshi, et al.
Publicado: (2017)

The effect of kidney function on the urate lowering effect and safety of increasing allopurinol above doses based on creatinine clearance: a post hoc analysis of a randomized controlled trial
por: Stamp, Lisa K., et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_11i1dckem11bihkom95lluei5s