From gene to dose: Long-read sequencing and *-allele tools to refine phenotype predictions of CYP2C19

Background: Inter-individual differences in drug response based on genetic variations can lead to drug toxicity and treatment inefficacy. A large part of this variability is caused by genetic variants in pharmacogenes. Unfortunately, the Single Nucleotide Variant arrays currently used in clinical ph...

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Detalles Bibliográficos
Autores principales: Graansma, Lonneke J., Zhai, Qinglian, Busscher, Loes, Menafra, Roberta, van den Berg, Redmar R., Kloet, Susan L., van der Lee, Maaike
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10014917/
https://www.ncbi.nlm.nih.gov/pubmed/36937863
http://dx.doi.org/10.3389/fphar.2023.1076574

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10014917/
https://www.ncbi.nlm.nih.gov/pubmed/36937863
http://dx.doi.org/10.3389/fphar.2023.1076574

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