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From gene to dose: Long-read sequencing and *-allele tools to refine phenotype predictions of CYP2C19
Background: Inter-individual differences in drug response based on genetic variations can lead to drug toxicity and treatment inefficacy. A large part of this variability is caused by genetic variants in pharmacogenes. Unfortunately, the Single Nucleotide Variant arrays currently used in clinical ph...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10014917/ https://www.ncbi.nlm.nih.gov/pubmed/36937863 http://dx.doi.org/10.3389/fphar.2023.1076574 |