Tp53 haploinsufficiency is involved in hotspot mutations and cytoskeletal remodeling in gefitinib-induced drug-resistant EGFR(L858R)-lung cancer mice

Tumor heterogeneity is the major factor for inducing drug resistance. p53 is the major defender to maintain genomic stability, which is a high proportion mutated in most of the cancer types. In this study, we established in vivo animal models of gefitinib-induced drug-resistant lung cancer containin...

Descripción completa

Detalles Bibliográficos
Autores principales: Wang, Yi-Shiang, Young, Ming-Jer, Liu, Chia-Yu, Chen, Yung-Ching, Hung, Jan-Jong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10015023/
https://www.ncbi.nlm.nih.gov/pubmed/36918558
http://dx.doi.org/10.1038/s41420-023-01393-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10015023/
https://www.ncbi.nlm.nih.gov/pubmed/36918558
http://dx.doi.org/10.1038/s41420-023-01393-2

Ejemplares similares