KDM6A Loss Triggers an Epigenetic Switch That Disrupts Urothelial Differentiation and Drives Cell Proliferation in Bladder Cancer

Disruption of KDM6A, a histone lysine demethylase, is one of the most common somatic alternations in bladder cancer. Insights into how KDM6A mutations affect the epigenetic landscape to promote carcinogenesis could help reveal potential new treatment approaches. Here, we demonstrated that KDM6A loss...

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Detalles Bibliográficos
Autores principales: Qiu, Hong, Makarov, Vladimir, Bolzenius, Jennifer K., Halstead, Angela, Parker, Yvonne, Wang, Allen, Iyer, Gopakumar V., Wise, Hannah, Kim, Daniel, Thayaparan, Varna, Lindner, Daniel J., Haber, Georges-Pascal, Ting, Angela H., Ren, Bing, Chan, Timothy A., Arora, Vivek, Solit, David B., Lee, Byron H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2023
Materias:
Genome and Epigenome
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10015223/
https://www.ncbi.nlm.nih.gov/pubmed/36638328
http://dx.doi.org/10.1158/0008-5472.CAN-22-1444

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10015223/
https://www.ncbi.nlm.nih.gov/pubmed/36638328
http://dx.doi.org/10.1158/0008-5472.CAN-22-1444

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