Hydrophobic Ion Pairing of Small Molecules: How to Minimize Premature Drug Release from SEDDS and Reach the Absorption Membrane in Intact Form

[Image: see text] The present work aimed to form hydrophobic ion pairs (HIPs) of a small molecule remaining inside the oily droplets of SEDDS to a high extent. HIPs of ethacridine and various surfactants classified by functional groups of phosphates, sulfates, and sulfonates were formed and precipit...

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Detalles Bibliográficos
Autores principales: Spleis, Helen, Federer, Christoph, Claus, Victor, Sandmeier, Matthias, Bernkop-Schnürch, Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10015432/
https://www.ncbi.nlm.nih.gov/pubmed/36786693
http://dx.doi.org/10.1021/acsbiomaterials.2c01504

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10015432/
https://www.ncbi.nlm.nih.gov/pubmed/36786693
http://dx.doi.org/10.1021/acsbiomaterials.2c01504

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