Cargando…
In Silico Evaluation of the Thr58-Associated Conserved Water with KRAS Switch-II Pocket Binders
[Image: see text] The KRAS switch-II pocket (SII-P) has proven to be one of the most successful tools for targeting KRAS with small molecules to date. This has been demonstrated with several KRAS(G12C)-targeting covalent inhibitors, already resulting in two FDA-approved drugs. Several earlier-stage...
| Autores principales: | , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical Society
2023
|
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10015465/ https://www.ncbi.nlm.nih.gov/pubmed/36854010 http://dx.doi.org/10.1021/acs.jcim.2c01479 |