Cargando…

LncRNA GAS5 suppresses TGF-β1-induced transformation of pulmonary pericytes into myofibroblasts by recruiting KDM5B and promoting H3K4me2/3 demethylation of the PDGFRα/β promoter

BACKGROUND: Idiopathic pulmonary fibrosis (IPF) is a condition that may cause persistent pulmonary damage. The transformation of pericytes into myofibroblasts has been recognized as a key player during IPF progression. This study aimed to investigate the functions of lncRNA growth arrest-specific tr...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Yichun, Chen, Diyu, Xie, Han, Zhou, Shuhua, Jia, Mingwang, He, Xiaobo, Guo, Feifei, Lai, Yihuan, Tang, Xiao Xiao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10015786/ https://www.ncbi.nlm.nih.gov/pubmed/36918759 http://dx.doi.org/10.1186/s10020-023-00620-x

Ejemplares similares

M2 Macrophages Promote PDGFRβ(+) Pericytes Migration After Spinal Cord Injury in Mice via PDGFB/PDGFRβ Pathway
por: Li, Ziyu, et al.
Publicado: (2021)

CD146 is essential for PDGFRβ-induced pericyte recruitment
por: Chen, Jianan, et al.
Publicado: (2017)

KDM5B demethylates H3K4 to recruit XRCC1 and promote chemoresistance
por: Xu, Wenxia, et al.
Publicado: (2018)

Notch1 promotes the pericyte-myofibroblast transition in idiopathic pulmonary fibrosis through the PDGFR/ROCK1 signal pathway
por: Wang, Yi-Chun, et al.
Publicado: (2019)

Interferon-γ blocks signalling through PDGFRβ in human brain pericytes
por: Jansson, Deidre, et al.
Publicado: (2016)

TGF-β promotes pericyte-myofibroblast transition in subretinal fibrosis through the Smad2/3 and Akt/mTOR pathways
por: Zhao, Zhenzhen, et al.
Publicado: (2022)

PDGFRβ promotes oncogenic progression via STAT3/STAT5 hyperactivation in anaplastic large cell lymphoma
por: Garces de los Fayos Alonso, I., et al.
Publicado: (2022)

H3K4me3 demethylation by the histone demethylase KDM5C/JARID1C promotes DNA replication origin firing
por: Rondinelli, Beatrice, et al.
Publicado: (2015)

Pericyte-Mediated Tissue Repair through PDGFRβ Promotes Peri-Infarct Astrogliosis, Oligodendrogenesis, and Functional Recovery after Acute Ischemic Stroke
por: Shibahara, Tomoya, et al.
Publicado: (2020)

Imatinib inhibits pericyte-fibroblast transition and inflammation and promotes axon regeneration by blocking the PDGF-BB/PDGFRβ pathway in spinal cord injury
por: Yao, Fei, et al.
Publicado: (2022)

Spatiotemporal dynamics of PDGFRβ expression in pericytes and glial scar formation in penetrating brain injuries in adults
por: Reeves, C., et al.
Publicado: (2019)

The PHD1 finger of KDM5B recognizes unmodified H3K4 during the demethylation of histone H3K4me2/3 by KDM5B
por: Zhang, Yan, et al.
Publicado: (2014)

Histone demethylase KDM5B catalyzed H3K4me3 demethylation to promote differentiation of bone marrow mesenchymal stem cells into cardiomyocytes
por: Wang, Zhen, et al.
Publicado: (2022)

KDM6B-mediated histone demethylation of LDHA promotes lung metastasis of osteosarcoma
por: Jiang, Yuhang, et al.
Publicado: (2021)

Characterisation of PDGF-BB:PDGFRβ signalling pathways in human brain pericytes: evidence of disruption in Alzheimer’s disease
por: Smyth, Leon C. D., et al.
Publicado: (2022)

Elevated PDGF‐BB from Bone Impairs Hippocampal Vasculature by Inducing PDGFRβ Shedding from Pericytes
por: Liu, Guanqiao, et al.
Publicado: (2023)

RNA-dependent chromatin localization of KDM4D lysine demethylase promotes H3K9me3 demethylation
por: Zoabi, Muhammad, et al.
Publicado: (2014)

Immunolocalization of platelet‐derived growth factor receptor‐β (PDGFR‐β) and pericytes in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL)
por: Craggs, Lucinda J.L., et al.
Publicado: (2015)

Ursodeoxycholic Acid Attenuates the Retinal Vascular Abnormalities in Anti-PDGFR-β Antibody-Induced Pericyte Depletion Mouse Models
por: Shiraya, Tomoyasu, et al.
Publicado: (2020)

PDGFRβ signaling regulates local inflammation and synergizes with hypercholesterolemia to promote atherosclerosis
por: He, Chaoyong, et al.
Publicado: (2015)

PDGFR‐β and kidney fibrosis
por: Ortiz, Alberto
Publicado: (2020)

Transactivation of PDGFRβ by dopamine D4 receptor does not require PDGFRβ dimerization
por: Chi, Sum Shing, et al.
Publicado: (2010)

Specific ablation of PDGFRβ-overexpressing pericytes with antibody-drug conjugate potently inhibits pathologic ocular neovascularization in mouse models
por: Lee, Seok Jae, et al.
Publicado: (2021)

BRWD3 promotes KDM5 degradation to maintain H3K4 methylation levels
por: Han, Dongsheng, et al.
Publicado: (2023)

BRWD3 promotes KDM5 degradation to maintain H3K4 methylation levels
por: Han, Dongsheng, et al.
Publicado: (2023)

Transplantation of EPCs overexpressing PDGFR-β promotes vascular repair in the early phase after vascular injury
por: Wang, Hang, et al.
Publicado: (2016)

Targeted Delivery to Tumor-associated Pericytes via an Affibody with High Affinity for PDGFRβ Enhances the in vivo Antitumor Effects of Human TRAIL
por: Tao, Ze, et al.
Publicado: (2017)

Choreography of methylation: KDM4C histone demethylation enables ALKBH5 m6A RNA demethylation to sustain AML stem cells
por: Sarma, Pranjal, et al.
Publicado: (2020)

TGF-β signaling promotes tumor vasculature by enhancing the pericyte-endothelium association
por: Zonneville, Justin, et al.
Publicado: (2018)

lncRNA MAGI2-AS3 Prevents the Development of HCC via Recruiting KDM1A and Promoting H3K4me2 Demethylation of the RACGAP1 Promoter
por: Pu, Jian, et al.
Publicado: (2019)

Drosophila Kdm4 demethylases in histone H3 lysine 9 demethylation and ecdysteroid signaling
por: Tsurumi, Amy, et al.
Publicado: (2013)

Regulation of PDGFR-β gene expression by targeting the G-vacancy bearing G-quadruplex in promoter
por: Chen, Juan-nan, et al.
Publicado: (2021)

Histone demethylase KDM5A promotes tumorigenesis of osteosarcoma tumor
por: Peng, Daohu, et al.
Publicado: (2021)

PDGFRβ regulates craniofacial development through homodimers and functional heterodimers with PDGFRα
por: Fantauzzo, Katherine A., et al.
Publicado: (2016)

Nuclear GSK3β promotes tumorigenesis by phosphorylating KDM1A and inducing its deubiquitination by USP22
por: Zhou, Aidong, et al.
Publicado: (2016)

CCL5 Neutralization Restricts Cancer Growth and Potentiates the Targeting of PDGFRβ in Colorectal Carcinoma
por: Cambien, Béatrice, et al.
Publicado: (2011)

BSCI-11. STROMAL PLATELET DERIVED GROWTH FACTOR RECEPTOR-β (PDGFRβ) PROMOTES BREAST CANCER BRAIN METASTASIS
por: Thies, Katie, et al.
Publicado: (2019)

KDM6B promotes ESCC cell proliferation and metastasis by facilitating C/EBPβ transcription
por: Qin, Mei, et al.
Publicado: (2021)

Endothelial PDGF-BB/PDGFR-β signaling promotes osteoarthritis by enhancing angiogenesis-dependent abnormal subchondral bone formation
por: Cui, Zhuang, et al.
Publicado: (2022)

Targeting the PDGF-B/PDGFR-β Interface with Destruxin A5 to Selectively Block PDGF-BB/PDGFR-ββ Signaling and Attenuate Liver Fibrosis
por: Wang, Xingqi, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_q8kugkvsnac5735me26lolmdqc