CD47 expression is critical for CAR T-cell survival in vivo

BACKGROUND: CD47 is an attractive immunotherapeutic target because it is highly expressed on multiple solid tumors. However, CD47 is also expressed on T cells. Limited studies have evaluated CD47-chimeric antigen receptor (CAR) T cells, and the role of CD47 in CAR T-cell function remains largely unk...

Descripción completa

Detalles Bibliográficos
Autores principales: Beckett, Alex N, Chockley, Peter, Pruett-Miller, Shondra M, Nguyen, Phuong, Vogel, Peter, Sheppard, Heather, Krenciute, Giedre, Gottschalk, Stephen, DeRenzo, Christopher
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2023
Materias:
Immune Cell Therapies and Immune Cell Engineering
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10016274/
https://www.ncbi.nlm.nih.gov/pubmed/36918226
http://dx.doi.org/10.1136/jitc-2022-005857

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10016274/
https://www.ncbi.nlm.nih.gov/pubmed/36918226
http://dx.doi.org/10.1136/jitc-2022-005857

Ejemplares similares