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CD47 expression is critical for CAR T-cell survival in vivo

BACKGROUND: CD47 is an attractive immunotherapeutic target because it is highly expressed on multiple solid tumors. However, CD47 is also expressed on T cells. Limited studies have evaluated CD47-chimeric antigen receptor (CAR) T cells, and the role of CD47 in CAR T-cell function remains largely unk...

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Detalles Bibliográficos
Autores principales:	Beckett, Alex N, Chockley, Peter, Pruett-Miller, Shondra M, Nguyen, Phuong, Vogel, Peter, Sheppard, Heather, Krenciute, Giedre, Gottschalk, Stephen, DeRenzo, Christopher
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2023
Materias:	Immune Cell Therapies and Immune Cell Engineering
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10016274/ https://www.ncbi.nlm.nih.gov/pubmed/36918226 http://dx.doi.org/10.1136/jitc-2022-005857

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