Drug repurposing screens identify compounds that inhibit α-synuclein oligomers' membrane disruption and block antibody interactions

Small soluble oligomers of the protein α-synuclein (αSO) have been linked to disruptions in neuronal homeostasis, contributing to the development of Parkinson's Disease (PD). While this makes αSO an obvious drug target, the development of effective therapeutics against αSO is challenged by its...

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Detalles Bibliográficos
Autores principales: Somavarapu, Arun Kumar, Kleijwegt, Giulia, Nagaraj, Madhu, Alam, Parvez, Nielsen, Janni, Otzen, Daniel E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2023
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10016340/
https://www.ncbi.nlm.nih.gov/pubmed/36937574
http://dx.doi.org/10.1039/d2sc05534a

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10016340/
https://www.ncbi.nlm.nih.gov/pubmed/36937574
http://dx.doi.org/10.1039/d2sc05534a

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