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B-cell epitope discovery: The first protein flexibility-based algorithm–Zika virus conserved epitope demonstration

Antibody-antigen interaction–at antigenic local environments called B-cell epitopes–is a prominent mechanism for neutralization of infection. Effective mimicry, and display, of B-cell epitopes is key to vaccine design. Here, a physical approach is evaluated for the discovery of epitopes which evolve...

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Detalles Bibliográficos
Autores principales: Biner, Daniel W., Grosch, Jason S., Ortoleva, Peter J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10016673/
https://www.ncbi.nlm.nih.gov/pubmed/36920995
http://dx.doi.org/10.1371/journal.pone.0262321