Structure of a HIV-1 IN-Allosteric inhibitor complex at 2.93 Å resolution: Routes to inhibitor optimization

HIV integrase (IN) inserts viral DNA into the host genome and is the target of the strand transfer inhibitors (STIs), a class of small molecules currently in clinical use. Another potent class of antivirals is the allosteric inhibitors of integrase, or ALLINIs. ALLINIs promote IN aggregation by stab...

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Detalles Bibliográficos
Autores principales: Eilers, Grant, Gupta, Kushol, Allen, Audrey, Montermoso, Saira, Murali, Hemma, Sharp, Robert, Hwang, Young, Bushman, Frederic D., Van Duyne, Gregory
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10016701/
https://www.ncbi.nlm.nih.gov/pubmed/36867659
http://dx.doi.org/10.1371/journal.ppat.1011097

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10016701/
https://www.ncbi.nlm.nih.gov/pubmed/36867659
http://dx.doi.org/10.1371/journal.ppat.1011097

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