Early Selection of the Amino Acid Alphabet Was Adaptively Shaped by Biophysical Constraints of Foldability

[Image: see text] Whereas modern proteins rely on a quasi-universal repertoire of 20 canonical amino acids (AAs), numerous lines of evidence suggest that ancient proteins relied on a limited alphabet of 10 “early” AAs and that the 10 “late” AAs were products of biosynthetic pathways. However, many n...

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Detalles Bibliográficos
Autores principales: Makarov, Mikhail, Sanchez Rocha, Alma C., Krystufek, Robin, Cherepashuk, Ivan, Dzmitruk, Volha, Charnavets, Tatsiana, Faustino, Anneliese M., Lebl, Michal, Fujishima, Kosuke, Fried, Stephen D., Hlouchova, Klara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10017022/
https://www.ncbi.nlm.nih.gov/pubmed/36826345
http://dx.doi.org/10.1021/jacs.2c12987

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10017022/
https://www.ncbi.nlm.nih.gov/pubmed/36826345
http://dx.doi.org/10.1021/jacs.2c12987

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