Discovery of Novel Human Constitutive Androstane Receptor Agonists with the Imidazo[1,2-a]pyridine Structure

[Image: see text] The nuclear constitutive androstane receptor (CAR, NR1I3) plays significant roles in many hepatic functions, such as fatty acid oxidation, biotransformation, liver regeneration, as well as clearance of steroid hormones, cholesterol, and bilirubin. CAR has been proposed as a hypothe...

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Detalles Bibliográficos
Autores principales: Mejdrová, Ivana, Dušek, Jan, Škach, Kryštof, Stefela, Alžbeta, Skoda, Josef, Chalupský, Karel, Dohnalová, Klára, Pavkova, Ivona, Kronenberger, Thales, Rashidian, Azam, Smutná, Lucie, Duchoslav, Vojtěch, Smutny, Tomas, Pávek, Petr, Nencka, Radim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10017030/
https://www.ncbi.nlm.nih.gov/pubmed/36756805
http://dx.doi.org/10.1021/acs.jmedchem.2c01140

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10017030/
https://www.ncbi.nlm.nih.gov/pubmed/36756805
http://dx.doi.org/10.1021/acs.jmedchem.2c01140

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