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Long-QT mutations in KCNE1 modulate the 17β-estradiol response of Kv7.1/KCNE1
Estradiol (17 [Formula: see text]-E2) is implicated in higher arrhythmia risk of women with congenital or acquired long-QT syndrome (LQTS) compared to men. However, the underlying mechanisms remain poorly understood, and little is known about the impact of LQTS-associated mutations. We show that 17...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Association for the Advancement of Science
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10017040/ https://www.ncbi.nlm.nih.gov/pubmed/36921038 http://dx.doi.org/10.1126/sciadv.ade7109 |