The BAF complex inhibitor pyrimethamine reverses HIV-1 latency in people with HIV-1 on antiretroviral therapy

Reactivation of the latent HIV-1 reservoir is a first step toward triggering reservoir decay. Here, we investigated the impact of the BAF complex inhibitor pyrimethamine on the reservoir of people living with HIV-1 (PLWH). Twenty-eight PLWH on suppressive antiretroviral therapy were randomized (1:1:...

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Detalles Bibliográficos
Autores principales: Prins, Henrieke A. B., Crespo, Raquel, Lungu, Cynthia, Rao, Shringar, Li, Letao, Overmars, Ronald J., Papageorgiou, Grigorius, Mueller, Yvonne M., Stoszko, Mateusz, Hossain, Tanvir, Kan, Tsung Wai, Rijnders, Bart J. A., Bax, Hannelore I., van Gorp, Eric C. M., Nouwen, Jan L., de Vries-Sluijs, Theodora E. M. S., Schurink, Carolina A. M., de Mendonça Melo, Mariana, van Nood, Els, Colbers, Angela, Burger, David, Palstra, Robert-Jan, van Kampen, Jeroen J. A., van de Vijver, David A. M. C., Mesplède, Thibault, Katsikis, Peter D., Gruters, Rob A., Koch, Birgit C. P., Verbon, Annelies, Mahmoudi, Tokameh, Rokx, Casper
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10017042/
https://www.ncbi.nlm.nih.gov/pubmed/36921041
http://dx.doi.org/10.1126/sciadv.ade6675

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10017042/
https://www.ncbi.nlm.nih.gov/pubmed/36921041
http://dx.doi.org/10.1126/sciadv.ade6675

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