Conserved allosteric inhibition mechanism in SLC1 transporters

Excitatory amino acid transporter 1 (EAAT1) is a glutamate transporter belonging to the SLC1 family of solute carriers. It plays a key role in the regulation of the extracellular glutamate concentration in the mammalian brain. The structure of EAAT1 was determined in complex with UCPH-101, apotent,...

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Detalles Bibliográficos
Autores principales: Dong, Yang, Wang, Jiali, Garibsingh, Rachel-Ann, Hutchinson, Keino, Shi, Yueyue, Eisenberg, Gilad, Yu, Xiaozhen, Schlessinger, Avner, Grewer, Christof
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2023
Materias:
Structural Biology and Molecular Biophysics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10017108/
https://www.ncbi.nlm.nih.gov/pubmed/36856089
http://dx.doi.org/10.7554/eLife.83464

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10017108/
https://www.ncbi.nlm.nih.gov/pubmed/36856089
http://dx.doi.org/10.7554/eLife.83464

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