Cargando…

Pip5k1c Loss in Chondrocytes Causes Spontaneous Osteoarthritic Lesions in Aged Mice

Osteoarthritis (OA) is the most common degenerative joint disease affecting the older populations globally. Phosphatidylinositol-4-phosphate 5-kinase type-1 gamma (Pip5k1c), a lipid kinase catalyzing the synthesis of phospholipid phosphatidylinositol 4,5-bisphosphate (PIP2), is involved in various c...

Descripción completa

Detalles Bibliográficos
Autores principales:	Qu, Minghao, Chen, Mingjue, Gong, Weiyuan, Huo, Shaochuan, Yan, Qinnan, Yao, Qing, Lai, Yumei, Chen, Di, Wu, Xiaohao, Xiao, Guozhi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	JKL International LLC 2023
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10017150/ https://www.ncbi.nlm.nih.gov/pubmed/37008048 http://dx.doi.org/10.14336/AD.2022.0828

Ejemplares similares

Kindlin-2 loss in condylar chondrocytes causes spontaneous osteoarthritic lesions in the temporomandibular joint in mice
por: Lai, Yumei, et al.
Publicado: (2022)

Loss of Pinch Proteins Causes Severe Degenerative Disc Disease-Like Lesions in Mice
por: Wu, Xiaohao, et al.
Publicado: (2023)

Kindlin-2 deletion in osteoprogenitors causes severe chondrodysplasia and low-turnover osteopenia in mice
por: Wu, Xiaohao, et al.
Publicado: (2021)

Comparison of Kindlin-2 deficiency-stimulated osteoarthritis-like lesions induced by Prg4(CreERT2) versus Aggrecan(CreERT2) transgene in mice
por: Yao, Qing, et al.
Publicado: (2023)

Osteoarthritis: pathogenic signaling pathways and therapeutic targets
por: Yao, Qing, et al.
Publicado: (2023)

Altered spontaneous calcium signaling of in situ chondrocytes in human osteoarthritic cartilage
por: Gong, Xiaoyuan, et al.
Publicado: (2017)

Loss of phosphatidylinositol-4-phosphate 5-kinase type-1 gamma (Pip5k1c) in mesenchymal stem cells leads to osteopenia by impairing bone remodeling
por: Yan, Qinnan, et al.
Publicado: (2022)

PGC-1α in osteoarthritic chondrocytes: From mechanism to target of action
por: Wang, Haochen, et al.
Publicado: (2023)

Effect of electromagnetic fields on human osteoarthritic and non-osteoarthritic chondrocytes
por: Redeker, Julia Isabelle, et al.
Publicado: (2017)

Identification of the calcitonin receptor in osteoarthritic chondrocytes
por: Segovia-Silvestre, Toni, et al.
Publicado: (2011)

Irisin Recovers Osteoarthritic Chondrocytes In Vitro
por: Vadalà, Gianluca, et al.
Publicado: (2020)

MTORC1 coordinates the autophagy and apoptosis signaling in articular chondrocytes in osteoarthritic temporomandibular joint
por: Yang, Hongxu, et al.
Publicado: (2019)

Kindlin-2 inhibits Nlrp3 inflammasome activation in nucleus pulposus to maintain homeostasis of the intervertebral disc
por: Chen, Sheng, et al.
Publicado: (2022)

Cell biology and functional genomics of osteoarthritic chondrocytes
por: Aigner, T, et al.
Publicado: (2003)

The effect of resveratrol on normal and osteoarthritic chondrocyte metabolism
por: Kim, H. J., et al.
Publicado: (2014)

Biological Effects of Phosphocitrate on Osteoarthritic Articular Chondrocytes
por: Sun, Yubo, et al.
Publicado: (2017)

Pleiotropic Roles of NOTCH1 Signaling in the Loss of Maturational Arrest of Human Osteoarthritic Chondrocytes
por: Minguzzi, Manuela, et al.
Publicado: (2021)

Proliferation and differentiation potential of chondrocytes from osteoarthritic patients
por: Tallheden, Tommi, et al.
Publicado: (2005)

Toll-like receptors in human chondrocytes and osteoarthritic cartilage
por: Sillat, Tarvo, et al.
Publicado: (2013)

Global, regional and national burden of low back pain 1990–2019: A systematic analysis of the Global Burden of Disease study 2019
por: Chen, Sheng, et al.
Publicado: (2021)

Investigation of the direct effects of salmon calcitonin on human osteoarthritic chondrocytes
por: Sondergaard, Bodil-Cecilie, et al.
Publicado: (2010)

Chondrocytes From Osteoarthritic and Chondrocalcinosis Cartilage Represent Different Phenotypes
por: Meyer, Franziska, et al.
Publicado: (2021)

Concentration-Dependent Effects of Cobalt and Chromium Ions on Osteoarthritic Chondrocytes
por: Bauer, Christoph, et al.
Publicado: (2019)

Conditioned serum in vitro treatment of chondrocyte pellets and osteoarthritic explants
por: Löfgren, Maria, et al.
Publicado: (2022)

Chondrogenic differentiation potential of osteoarthritic chondrocytes and their possible use in matrix-associated autologous chondrocyte transplantation
por: Dehne, Tilo, et al.
Publicado: (2009)

Effects of low-intensity pulsed ultrasound and hyperbaric oxygen on human osteoarthritic chondrocytes
por: Yuan, Li-Jen, et al.
Publicado: (2014)

Chondrocyte number and proteoglycan synthesis in the ageing and osteoarthritic human articular cartilage
por: Bobacz, K, et al.
Publicado: (2003)

Characterization of microRNA expression profiles in normal and osteoarthritic human chondrocytes
por: Díaz-Prado, Silvia, et al.
Publicado: (2012)

Xanthine Oxidoreductase Is Involved in Chondrocyte Mineralization and Expressed in Osteoarthritic Damaged Cartilage
por: Nasi, Sonia, et al.
Publicado: (2021)

Targeting Human Osteoarthritic Chondrocytes with Ligand Directed Bacteriophage-Based Particles
por: Chongchai, Aitthiphon, et al.
Publicado: (2021)

Polyphenols suppress inducible oxidative stress in human osteoarthritic and bovine chondrocytes
por: Yagi, Haruyo, et al.
Publicado: (2020)

Development of a DNA damage-induced senescence model in osteoarthritic chondrocytes
por: Georget, Mélina, et al.
Publicado: (2023)

Chondrocyte Homeostasis and Differentiation: Transcriptional Control and Signaling in Healthy and Osteoarthritic Conditions
por: Michelacci, Yara M., et al.
Publicado: (2023)

Protective effects of aucubin on osteoarthritic chondrocyte model induced by hydrogen peroxide and mechanical stimulus
por: Young, In-Chi, et al.
Publicado: (2017)

Systematic Analysis of Transcriptomic Profile of Chondrocytes in Osteoarthritic Knee Using Next-Generation Sequencing and Bioinformatics
por: Chen, Yi-Jen, et al.
Publicado: (2018)

Up-regulation of P21-activated kinase 1 in osteoarthritis chondrocytes is responsible for osteoarthritic cartilage destruction
por: Ma, Wanli, et al.
Publicado: (2020)

Collagen 2A Type B Induction after 3D Bioprinting Chondrocytes In Situ into Osteoarthritic Chondral Tibial Lesion
por: Gatenholm, Birgitta, et al.
Publicado: (2020)

In vivo visualization of osteoarthritic hypertrophic lesions
por: Hu, Hai-Yu, et al.
Publicado: (2015)

Hyaluronan inhibits expression of ADAMTS4 (aggrecanase-1) in human osteoarthritic chondrocytes
por: Yatabe, T, et al.
Publicado: (2009)

Regulation of SOX9 in normal and osteoarthritic equine articular chondrocytes by hyperosmotic loading
por: Peffers, M.J., et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_au5ou9sderaa27mgpg962a17pi