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DNA methyltransferase inhibition induces dynamic gene expression changes in lung CD4(+) T cells of neonatal mice with E. coli pneumonia

Bacterial pulmonary infections are a major cause of morbidity and mortality in neonates, with less severity in older children. Previous studies demonstrated that the DNA of CD4(+) T cells in the mouse lung, whose primary responsibility is to coordinate the immune response to foreign pathogens, is di...

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Detalles Bibliográficos
Autores principales: Michki, Nigel S., Ndeh, Roland, Helmin, Kathryn A., Singer, Benjamin D., McGrath-Morrow, Sharon A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10017701/
https://www.ncbi.nlm.nih.gov/pubmed/36922640
http://dx.doi.org/10.1038/s41598-023-31285-5