Spontaneously evolved progenitor niches escape Yap oncogene addiction in advanced pancreatic ductal adenocarcinomas

Lineage plasticity has been proposed as a major source of intratumoral heterogeneity and therapeutic resistance. Here, by employing an inducible genetic engineered mouse model, we illustrate that lineage plasticity enables advanced Pancreatic Ductal Adenocarcinoma (PDAC) tumors to develop spontaneou...

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Detalles Bibliográficos
Autores principales: Murakami, Shigekazu, White, Shannon M., McIntosh, Alec T., Nguyen, Chan D. K., Yi, Chunling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10017707/
https://www.ncbi.nlm.nih.gov/pubmed/36922511
http://dx.doi.org/10.1038/s41467-023-37147-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10017707/
https://www.ncbi.nlm.nih.gov/pubmed/36922511
http://dx.doi.org/10.1038/s41467-023-37147-y

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