Myoscaffolds reveal laminin scarring is detrimental for stem cell function while sarcospan induces compensatory fibrosis

We developed an on-slide decellularization approach to generate acellular extracellular matrix (ECM) myoscaffolds that can be repopulated with various cell types to interrogate cell-ECM interactions. Using this platform, we investigated whether fibrotic ECM scarring affected human skeletal muscle pr...

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Detalles Bibliográficos
Autores principales: Stearns-Reider, Kristen M., Hicks, Michael R., Hammond, Katherine G., Reynolds, Joseph C., Maity, Alok, Kurmangaliyev, Yerbol Z., Chin, Jesse, Stieg, Adam Z., Geisse, Nicholas A., Hohlbauch, Sophia, Kaemmer, Stefan, Schmitt, Lauren R., Pham, Thanh T., Yamauchi, Ken, Novitch, Bennett G., Wollman, Roy, Hansen, Kirk C., Pyle, April D., Crosbie, Rachelle H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10017766/
https://www.ncbi.nlm.nih.gov/pubmed/36922514
http://dx.doi.org/10.1038/s41536-023-00287-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10017766/
https://www.ncbi.nlm.nih.gov/pubmed/36922514
http://dx.doi.org/10.1038/s41536-023-00287-2

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