Physiologically based kinetic modeling of senecionine N-oxide in rats as a new approach methodology to define the effects of dose and endpoint used on relative potency values of pyrrolizidine alkaloid N-oxides

Over 1,000 pyrrolizidine alkaloids (PAs) and their N-oxides (PA-N-oxides) occur in 3% of all flowering plants. PA-N-oxides are toxic when reduced to their parent PAs, which are bioactivated into pyrrole intermediates that generate protein- and DNA-adducts resulting in liver toxicity and carcinogenic...

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Detalles Bibliográficos
Autores principales: Widjaja, Frances, Zheng, Liang, Wesseling, Sebastiaan, Rietjens, Ivonne M. C. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10017778/
https://www.ncbi.nlm.nih.gov/pubmed/36937884
http://dx.doi.org/10.3389/fphar.2023.1125146

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10017778/
https://www.ncbi.nlm.nih.gov/pubmed/36937884
http://dx.doi.org/10.3389/fphar.2023.1125146

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