The role of ADAM17 in cerebrovascular and cognitive function in the APP/PS1 mouse model of Alzheimer’s disease

INTRODUCTION: The disintegrin and metalloproteinase 17 (ADAM17) exhibits α-secretase activity, whereby it can prevent the production of neurotoxic amyloid precursor protein-α (APP). ADAM17 is abundantly expressed in vascular endothelial cells and may act to regulate vascular homeostatic responses, i...

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Detalles Bibliográficos
Autores principales: Tian, Yanna, Fopiano, Katie Anne, Buncha, Vadym, Lang, Liwei, Suggs, Hayden A., Wang, Rongrong, Rudic, R. Daniel, Filosa, Jessica A., Bagi, Zsolt
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Molecular Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10018024/
https://www.ncbi.nlm.nih.gov/pubmed/36937050
http://dx.doi.org/10.3389/fnmol.2023.1125932

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10018024/
https://www.ncbi.nlm.nih.gov/pubmed/36937050
http://dx.doi.org/10.3389/fnmol.2023.1125932

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