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The role of ADAM17 in cerebrovascular and cognitive function in the APP/PS1 mouse model of Alzheimer’s disease

INTRODUCTION: The disintegrin and metalloproteinase 17 (ADAM17) exhibits α-secretase activity, whereby it can prevent the production of neurotoxic amyloid precursor protein-α (APP). ADAM17 is abundantly expressed in vascular endothelial cells and may act to regulate vascular homeostatic responses, i...

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Detalles Bibliográficos
Autores principales:	Tian, Yanna, Fopiano, Katie Anne, Buncha, Vadym, Lang, Liwei, Suggs, Hayden A., Wang, Rongrong, Rudic, R. Daniel, Filosa, Jessica A., Bagi, Zsolt
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Molecular Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10018024/ https://www.ncbi.nlm.nih.gov/pubmed/36937050 http://dx.doi.org/10.3389/fnmol.2023.1125932

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