Cargando…

Artemisinin exerts a protective effect in the MPTP mouse model of Parkinson's disease by inhibiting microglial activation via the TLR4/Myd88/NF‐KB pathway

AIMS: We performed cell and animal experiments to explore the therapeutic effect of artemisinin on Parkinson's disease (PD) and the TLR4/Myd88 signaling pathway. METHODS: C57 mice were randomly divided into the blank, 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine (MPTP)‐induced and artemisinin‐t...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lv, Jing, Zhu, Jing, Wang, Peihan, Liu, Tongyu, Yuan, Jiang, Yin, Huan, Lan, Yiran, Sun, Qiang, Zhang, Zhifeng, Ding, Guoda, Zhou, Chenxi, Wang, Huajie, Wang, Zihan, Wang, Yunfu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2023
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10018080/ https://www.ncbi.nlm.nih.gov/pubmed/36691817 http://dx.doi.org/10.1111/cns.14063

Ejemplares similares

Rapamycin reverses ferroptosis by increasing autophagy in MPTP/MPP(+)-induced models of Parkinson’s disease
por: Liu, Tongyu, et al.
Publicado: (2023)

The role of the MYD88-dependent pathway in MPTP-induced brain dopaminergic degeneration
por: Drouin-Ouellet, Janelle, et al.
Publicado: (2011)

Schisandrin B Attenuates Diabetic Cardiomyopathy by Targeting MyD88 and Inhibiting MyD88‐Dependent Inflammation
por: Luo, Wu, et al.
Publicado: (2022)

SYK is activated by mutated MYD88 and drives pro-survival signaling in MYD88 driven B-cell lymphomas
por: Munshi, Manit, et al.
Publicado: (2020)

MyD88 Mediates Colitis- and RANKL-Induced Microfold Cell Differentiation
por: Li, Yang, et al.
Publicado: (2021)

MyD88 deficiency aggravates the severity of acute pancreatitis by promoting MyD88-independent TRIF pathway-mediated necrosis
por: Yang, Du-Jiang, et al.
Publicado: (2022)

Necrotic neurons enhance microglial neurotoxicity through induction of glutaminase by a MyD88-dependent pathway
por: Pais, Teresa F, et al.
Publicado: (2008)

Identification and Function of Myeloid Differentiation Factor 88 (MyD88) in Litopenaeus vannamei
por: Zhang, Shuang, et al.
Publicado: (2012)

MyD88 Polymorphisms and Association with Susceptibility to Salmonella Pullorum
por: Liu, Xian-Qing, et al.
Publicado: (2015)

Two Human MYD88 Variants, S34Y and R98C, Interfere with MyD88-IRAK4-Myddosome Assembly
por: George, Julie, et al.
Publicado: (2011)

MyD88 and beyond: a perspective on MyD88-targeted therapeutic approach for modulation of host immunity
por: Saikh, Kamal U.
Publicado: (2021)

Toll-Like Receptors and Cancer: MYD88 Mutation and Inflammation
por: Wang, James Q., et al.
Publicado: (2014)

Astragalus polysaccharides exerts immunomodulatory effects via TLR4-mediated MyD88-dependent signaling pathway in vitro and in vivo
por: Zhou, Lijing, et al.
Publicado: (2017)

TLR4-MyD88/Mal-NF-kB Axis Is Involved in Infection of HSV-2 in Human Cervical Epithelial Cells
por: Liu, Hongya, et al.
Publicado: (2013)

A MyD88 meddles with survival
por: Bashyam, Hema
Publicado: (2007)

Role of MyD88 in Adenovirus Keratitis
por: Zhou, Xiaohong, et al.
Publicado: (2016)

Blockade of Myd88 signaling by a novel MyD88 inhibitor prevents colitis-associated colorectal cancer development by impairing myeloid-derived suppressor cells
por: Wang, Lu, et al.
Publicado: (2022)

Effect of TLR4/MyD88/NF‐kB axis in paraventricular nucleus on ventricular arrhythmias induced by sympathetic hyperexcitation in post‐myocardial infarction rats
por: Wang, Kang, et al.
Publicado: (2022)

Isobavachalcone Attenuates MPTP-Induced Parkinson's Disease in Mice by Inhibition of Microglial Activation through NF-κB Pathway
por: Jing, Haoran, et al.
Publicado: (2017)

Microglial cGAS drives neuroinflammation in the MPTP mouse models of Parkinson's disease
por: Ma, Chunmei, et al.
Publicado: (2023)

Thymol Ameliorates Aspergillus fumigatus Keratitis by Downregulating the TLR4/ MyD88/ NF-kB/ IL-1β Signal Expression and Reducing Necroptosis and Pyroptosis
por: Wang, Limei, et al.
Publicado: (2023)

Expression of TLR-7, MyD88, NF-kB, and INF-α in B Lymphocytes of Mayan Women with Systemic Lupus Erythematosus in Mexico
por: Pacheco, Guillermo Valencia, et al.
Publicado: (2016)

Soyasaponins reduce inflammation by downregulating MyD88 expression and suppressing the recruitments of TLR4 and MyD88 into lipid rafts
por: Chen, Junbin, et al.
Publicado: (2020)

Catalpol Exerts a Neuroprotective Effect in the MPTP Mouse Model of Parkinson’s Disease
por: Wang, Li-Yuan, et al.
Publicado: (2019)

Myd88 Is Required for an Antibody Response to Retroviral Infection
por: Browne, Edward P., et al.
Publicado: (2009)

MyD88 contribution to ocular surface homeostasis
por: Reins, Rose Y., et al.
Publicado: (2017)

Mechanism of MyD88S mediated signal termination
por: Pustelny, Katarzyna, et al.
Publicado: (2022)

A Novel Kindred with MyD88 Deficiency
por: Bucciol, Giorgia, et al.
Publicado: (2022)

Papaverine Exerts Neuroprotective Effect by Inhibiting NLRP3 Inflammasome Activation in an MPTP-Induced Microglial Priming Mouse Model Challenged with LPS
por: Leem, Yea-Hyun, et al.
Publicado: (2021)

Mucus clearance, MyD88-dependent and MyD88-independent immunity modulate lung susceptibility to spontaneous bacterial infection and inflammation
por: Livraghi-Butrico, Alessandra, et al.
Publicado: (2012)

From monogenic lupus to TLR7/MyD88-targeted therapy
por: Wang, Min, et al.
Publicado: (2022)

Severity of DSS-induced colitis is reduced in Ido1-deficient mice with down-regulation of TLR-MyD88-NF-kB transcriptional networks
por: Shon, Woo-Jeong, et al.
Publicado: (2015)

LncRNA MALAT1 promotes high glucose-induced inflammatory response of microglial cells via provoking MyD88/IRAK1/TRAF6 signaling
por: Wang, Li-Qing, et al.
Publicado: (2018)

Expression of TLR4-MyD88 and NF-κB in the Iris during Endotoxin-Induced Uveitis
por: Li, Shang, et al.
Publicado: (2010)

Baicalin Rescues Cognitive Dysfunction, Mitigates Neurodegeneration, and Exerts Anti-Epileptic Effects Through Activating TLR4/MYD88/Caspase-3 Pathway in Rats
por: Yang, Jiali, et al.
Publicado: (2021)

Vitamin D Protects against Traumatic Brain Injury via Modulating TLR4/MyD88/NF-κB Pathway-Mediated Microglial Polarization and Neuroinflammation
por: Jiang, Hongsheng, et al.
Publicado: (2022)

High-resolution melting analysis for rapid and sensitive MYD88 screening in chronic lymphocytic leukemia
por: Jiang, Min, et al.
Publicado: (2019)

High-resolution melting analysis for rapid and sensitive MYD88 screening in chronic lymphocytic leukemia
por: Jiang, Min, et al.
Publicado: (2019)

Myeloid Differentiation Factor 88 (MyD88)-Deficiency Increases Risk of Diabetes in Mice
por: Hosoi, Toru, et al.
Publicado: (2010)

Phyllanthus amarus prevents LPS-mediated BV2 microglial activation via MyD88 and NF-κB signaling pathways
por: Ismail, Elysha Nur, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_gimdfqlisrr0c1epk81805h0o0