Cargando…

Hsc70 rescues the synaptic vesicle trafficking defects caused by α-synuclein dimers

Aberrant buildup of α-synuclein is associated with Parkinson’s disease (PD) and other neurodegenerative disorders. At synapses, α-synuclein accumulation leads to severe synaptic vesicle trafficking defects. We previously demonstrated that different molecular species of α-synuclein produce distinct e...

Descripción completa

Detalles Bibliográficos
Autores principales:	Brady, Emily B., McQuillan, Molly, Medeiros, Audrey T., Bubacco, Luigi, Sousa, Rui, Lafer, Eileen M., Morgan, Jennifer R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Caltech Library 2023
Materias:	New Finding
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10018313/ https://www.ncbi.nlm.nih.gov/pubmed/36938331 http://dx.doi.org/10.17912/micropub.biology.000737

Ejemplares similares

Hsc70 Ameliorates the Vesicle Recycling Defects Caused by Excess α-Synuclein at Synapses
por: Banks, Susan M. L., et al.
Publicado: (2020)

UNC-33L partially rescues life span and locomotion defects in unc-33 mutants but fails to rescue dauer formation defects.
por: Lopez, Melissa E, et al.
Publicado: (2022)

Human PERK rescues unfolded protein response-deficient yeast cells
por: Yap, Wei Sheng, et al.
Publicado: (2022)

Phylogenetic annotation of Drosophila melanogaster heat shock protein 70 genes
por: Kaneko, Gen
Publicado: (2022)

Phylogenetic annotation of Caenorhabditis elegans heat shock protein 70 genes
por: Hasnain, Pirzada, et al.
Publicado: (2022)

Swimming exercise reduces native ⍺-synuclein protein species in a transgenic C. elegans model of Parkinson’s disease.
por: Schmidt, Minna Y., et al.
Publicado: (2021)

α-Synuclein Dimers Impair Vesicle Fission during Clathrin-Mediated Synaptic Vesicle Recycling
por: Medeiros, Audrey T., et al.
Publicado: (2017)

unc-119 mutants have an increased fungal spore adhesion that is not rescued by Cb-unc-119
por: Omi, Shizue, et al.
Publicado: (2021)

Disruption of GRR1 in Saccharomyces cerevisiae rescues tps1Δ growth on fermentable carbon sources
por: Chen, Anqi, et al.
Publicado: (2023)

SGS1-SuOff rescues the mild methylmethane sulfonate sensitivity of srs2Δ cells in Saccharomyces cerevisiae
por: Herce-Hagiwara, Belen, et al.
Publicado: (2021)

Minimum number of synaptic vesicles for the initiation of a single action potential at C. elegans neuromuscular junction
por: Chen, Lili, et al.
Publicado: (2020)

Anti-oxidant MitoQ rescue of AWB chemosensory neuron impairment in a C. elegans model of X-linked Adrenoleukodystrophy
por: Guha, Sanjib, et al.
Publicado: (2021)

The regulation of lipid and carbohydrate storage by the splicing factor gene snRNP-U1-70K in the Drosophila fat body
por: Shabar, Hamza, et al.
Publicado: (2022)

Gene bashing of ceh-6 locus identifies genomic regions important for ceh-6 rectal cell expression and rescue of its mutant lethality
por: Ahier, Arnaud, et al.
Publicado: (2020)

Temperature-sensitive mosquito TRP channel rescues touch deficits caused by knock-out of a DEG/ENaC channel in C. elegans glia
por: Wang, Ying, et al.
Publicado: (2020)

ceh-84, an unusual homeobox gene
por: Reilly, Molly, et al.
Publicado: (2020)

A mutation in budding yeast BRR6 affecting nuclear envelope insertion of the spindle pole body
por: Gardner, Jennifer M, et al.
Publicado: (2021)

A single copy transgenic mutant FUS strain reproduces age-dependent ALS phenotypes in C. elegans
por: Labarre, Audrey, et al.
Publicado: (2021)

The disconnect2 mutation disrupts the tjp1b gene that is required for electrical synapse formation
por: Michel, Jennifer Carlisle, et al.
Publicado: (2022)

Chaperone proteins as ameliorators of α-synuclein-induced synaptic pathologies: insights into Parkinson’s disease
por: Banks, Susan M.L., et al.
Publicado: (2020)

YML018C protein localizes to the vacuolar membrane independently of Atg27p
por: Sturgeon, Candyce M., et al.
Publicado: (2021)

B.2.16 is a non-lethal modifier of the Dark(82) mosaic eye phenotype in Drosophila melanogaster
por: Vrailas-Mortimer, Alysia D, et al.
Publicado: (2021)

Effects of Excess Brain-Derived Human α-Synuclein on Synaptic Vesicle Trafficking
por: Román-Vendrell, Cristina, et al.
Publicado: (2021)

C. elegans CYLC-2 localizes to sperm
por: Krauchunas, Amber R, et al.
Publicado: (2020)

The ER glycoprotein folding sensor UDP-Glc: glycoprotein glucosyltransferase is broadly expressed in C. elegans hermaphrodite
por: Buzzi, Lucila, et al.
Publicado: (2020)

The muscarinic agonist arecoline suppresses motor circuit hyperactivity in C. elegans
por: McCulloch, Katherine A, et al.
Publicado: (2020)

Plant hexokinase phylogenetic analysis highlights a possible regulation by the posttranslational modifier SUMO
por: Castro, Pedro Humberto, et al.
Publicado: (2020)

Arabidopsis thaliana growth is independently controlled by the SUMO E3 ligase SIZ1 and Hexokinase 1
por: Castro, Pedro Humberto, et al.
Publicado: (2020)

Codon optimized Tol2 transposase results in increased transient expression of a crystallin-GFP transgene in zebrafish
por: Mackey, Allison S., et al.
Publicado: (2020)

A toolkit of tagged glp-1 alleles reveals strong glp-1 expression in the germline, embryo, and spermatheca
por: Sorensen, Erika B, et al.
Publicado: (2020)

Novel actions of arecoline in the C. elegans motor circuit
por: McCulloch, Katherine A, et al.
Publicado: (2020)

A role for Arabidopsis myosins in sugar-induced hypocotyl elongation
por: Olatunji, Damilola, et al.
Publicado: (2020)

Using the C. elegans lem-2 Gene to Reconstruct the Human LEMD2 Mutation Associated with Hutterite-type Cataract/Cardiomyopathy
por: AlKhaleefa, Ayaa, et al.
Publicado: (2020)

Overactive EGF signaling promotes uv1 cell survival via increased phosphatidylcholine levels and suppression of SBP-1
por: Crook, Matt, et al.
Publicado: (2020)

The salt-inducible kinase KIN-29 regulates lifespan via the class II histone-deacetylase HDA-4
por: Nikooei, Tatiana, et al.
Publicado: (2020)

Blocking Wallerian degeneration by loss of Sarm1 does not promote axon resealing in zebrafish
por: Tian, Weili, et al.
Publicado: (2020)

Vitellogenin-2 acts downstream of PRY-1/Axin to regulate lipids and lifespan in C. elegans
por: Mallick, Avijit, et al.
Publicado: (2020)

The teratogenic effect of Triclosan on embryogenesis is attenuated by Tween 20 in Caenorhabditis elegans
por: Park, Youngyong, et al.
Publicado: (2020)

Arabidopsis Heat Shock Granules exhibit dynamic cellular behavior and can form in response to protein misfolding in the absence of elevated temperatures
por: Lawrence, Rosalie, et al.
Publicado: (2020)

Exposing a novel genetic interaction between unc-33/CRMP and hmp-2/β-catenin during Caenorhabditis elegans embryogenesis
por: Garzanelli, John, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_s57b57974p9kqf5dmpg24bj1ql