Conservation of transcriptional regulation by BRCA1 and BARD1 in Caenorhabditis elegans

The tumor-suppressor proteins BRCA1 and BARD1 function as an E3 ubiquitin ligase to facilitate transcriptional repression and DNA damage repair. This is mediated in-part through its ability to mono-ubiquitylate histone H2A in nucleosomes. Studies in Caenorhabditis elegans have been used to elucidate...

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Detalles Bibliográficos
Autores principales: Thapa, Ishor, Vahrenkamp, Russell, Witus, Samuel R, Lightle, Caitlin, Falkenberg, Owen, Sellin Jeffries, Marlo K, Klevit, Rachel E, Stewart, Mikaela D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Gene regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10018340/
https://www.ncbi.nlm.nih.gov/pubmed/36250637
http://dx.doi.org/10.1093/nar/gkac877

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10018340/
https://www.ncbi.nlm.nih.gov/pubmed/36250637
http://dx.doi.org/10.1093/nar/gkac877

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