Cargando…
Structure and functional determinants of Rad6–Bre1 subunits in the histone H2B ubiquitin-conjugating complex
The conserved complex of the Rad6 E2 ubiquitin-conjugating enzyme and the Bre1 E3 ubiquitin ligase catalyzes histone H2B monoubiquitination (H2Bub1), which regulates chromatin dynamics during transcription and other nuclear processes. Here, we report a crystal structure of Rad6 and the non-RING doma...
Autores principales: | , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10018343/ https://www.ncbi.nlm.nih.gov/pubmed/36715322 http://dx.doi.org/10.1093/nar/gkad012 |