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Structure and functional determinants of Rad6–Bre1 subunits in the histone H2B ubiquitin-conjugating complex

The conserved complex of the Rad6 E2 ubiquitin-conjugating enzyme and the Bre1 E3 ubiquitin ligase catalyzes histone H2B monoubiquitination (H2Bub1), which regulates chromatin dynamics during transcription and other nuclear processes. Here, we report a crystal structure of Rad6 and the non-RING doma...

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Detalles Bibliográficos
Autores principales:	Shukla, Prakash K, Bissell, Jesse E, Kumar, Sanjit, Pokhrel, Srijana, Palani, Sowmiya, Radmall, Kaitlin S, Obidi, Onyeka, Parnell, Timothy J, Brasch, Julia, Shrieve, Dennis C, Chandrasekharan, Mahesh B
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2023
Materias:	Gene regulation, Chromatin and Epigenetics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10018343/ https://www.ncbi.nlm.nih.gov/pubmed/36715322 http://dx.doi.org/10.1093/nar/gkad012

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