A shared ‘vulnerability code’ underpins varying sources of DNA damage throughout paternal germline transmission in mouse

During mammalian spermatogenesis, the paternal genome is extensively remodelled via replacement of histones with protamines forming the highly compact mature sperm nucleus. Compaction occurs in post-meiotic spermatids and is accompanied by extensive double strand break (DSB) formation. We investigat...

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Detalles Bibliográficos
Autores principales: Burden, Frances, Ellis, Peter J I, Farré, Marta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Genomics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10018361/
https://www.ncbi.nlm.nih.gov/pubmed/36806949
http://dx.doi.org/10.1093/nar/gkad089

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10018361/
https://www.ncbi.nlm.nih.gov/pubmed/36806949
http://dx.doi.org/10.1093/nar/gkad089

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