Computational design of fusion proteins against ErbB2-amplified tumors inspired by ricin toxin

Although the anti-cancer activity of ricin is well-known, its non-specific targeting challenges the development of ricin-derived medicines. In the present study, novel potential ribosome-inactivating fusion proteins (RIPs) were computationally engineered by incorporation of an ErbB2-dependant penetr...

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Detalles Bibliográficos
Autores principales: Ahmadi Moghaddam, Yasser, Maroufi, Asad, Zareei, Sara, Irani, Mehdi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Molecular Biosciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10018397/
https://www.ncbi.nlm.nih.gov/pubmed/36936983
http://dx.doi.org/10.3389/fmolb.2023.1098365

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10018397/
https://www.ncbi.nlm.nih.gov/pubmed/36936983
http://dx.doi.org/10.3389/fmolb.2023.1098365

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