Cargando…
Computational design of fusion proteins against ErbB2-amplified tumors inspired by ricin toxin
Although the anti-cancer activity of ricin is well-known, its non-specific targeting challenges the development of ricin-derived medicines. In the present study, novel potential ribosome-inactivating fusion proteins (RIPs) were computationally engineered by incorporation of an ErbB2-dependant penetr...
| Autores principales: | , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2023
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10018397/ https://www.ncbi.nlm.nih.gov/pubmed/36936983 http://dx.doi.org/10.3389/fmolb.2023.1098365 |