Enhancing response of a protein conformational switch by using two disordered ligand binding domains

Introduction: Protein conformational switches are often constructed by fusing an input domain, which recognizes a target ligand, to an output domain that establishes a biological response. Prior designs have employed binding-induced folding of the input domain to drive a conformational change in the...

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Detalles Bibliográficos
Autores principales: Sekhon, Harsimranjit, Ha, Jeung-Hoi, Loh, Stewart N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Molecular Biosciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10018487/
https://www.ncbi.nlm.nih.gov/pubmed/36936990
http://dx.doi.org/10.3389/fmolb.2023.1114756

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10018487/
https://www.ncbi.nlm.nih.gov/pubmed/36936990
http://dx.doi.org/10.3389/fmolb.2023.1114756

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