Cargando…
Enhancing response of a protein conformational switch by using two disordered ligand binding domains
Introduction: Protein conformational switches are often constructed by fusing an input domain, which recognizes a target ligand, to an output domain that establishes a biological response. Prior designs have employed binding-induced folding of the input domain to drive a conformational change in the...
| Autores principales: | , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2023
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10018487/ https://www.ncbi.nlm.nih.gov/pubmed/36936990 http://dx.doi.org/10.3389/fmolb.2023.1114756 |