The I148M PNPLA3 variant mitigates niacin beneficial effects: How the genetic screening in non-alcoholic fatty liver disease patients gains value

BACKGROUND: The PNPLA3 p.I148M impact on fat accumulation can be modulated by nutrients. Niacin (Vitamin B3) reduced triglycerides synthesis in in vitro and in vivo NAFLD models. OBJECTIVES: In this study, we aimed to investigate the niacin-I148M polymorphism crosstalk in NAFLD patients and examine...

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Detalles Bibliográficos
Autores principales: Paolini, Erika, Longo, Miriam, Meroni, Marica, Tria, Giada, Cespiati, Annalisa, Lombardi, Rosa, Badiali, Sara, Maggioni, Marco, Fracanzani, Anna Ludovica, Dongiovanni, Paola
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Nutrition
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10018489/
https://www.ncbi.nlm.nih.gov/pubmed/36937355
http://dx.doi.org/10.3389/fnut.2023.1101341

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10018489/
https://www.ncbi.nlm.nih.gov/pubmed/36937355
http://dx.doi.org/10.3389/fnut.2023.1101341

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